![]() It is generally believed that SWds are generalized, with a sudden onset. Generalized seizures like absence seizures are associated with spike-and-wave discharges (SWd, Fig.1) (Gloor and Fariello, 1988 Loiseau, 1992 Mirsky et al., 1986 Passouant, 1991). Theoretically, a "preictal state" can be defined as a period, within which the epileptic brain activity inevitably evolves into a seizure if no kind of interruption occurs (Lehnertz et al 2001). ![]() Data-driven approach Generalized seizures Using data-driven and model-based approaches, we investigated changes in the brain dynamics in preictal periods in patients with generalized and partial seizures. Moreover, reliable seizure prediction methods can considerably improve the quality of life of epileptic patients. The identification of early changes in preictal periods may provide valuable insight into such mechanisms. This feeling is different from an aura, which is characterized by distinct visual, motor, sensory, or psychological perceptions felt within a few seconds to one hour prior to seizures (Alvarez-Silva et al 2006). However, some patients feel a premonitory phase minutes to hours prior to seizures (Rajna et al 1997). This is why epileptic patients are often at high risk of severe injury or death. Seizures often start suddenly in an unpredictable way. ![]() Although the pathophysiological processes underlying epileptic neural activities are known, the mechanisms involved in the generation and propagation of epileptic seizures are still unknown. Resulting of abnormal complex dynamical interactions between different cerebral regions, epileptic seizures are often characterized by the intermittent occurrence of synchronous paroxysmal activities. Epilepsy causes recurrent aberrant hypersynchronous electrical discharges in the brain (Chaovalitwongse et al 2006). ![]()
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